It depends on what you want from the tank. I want a slice of the lake, so I avoid hybrids. Although I have dipped into a line-bred peacock or two.

I do like the turkis! And I take liberties like putting Tang cats in Malawi tanks. BN plecos. Nerite snails. The wrong rocks/plants.
I also have limited tank space and prefer not to cull fish (even for resale). So it is worth it to me to stock the tank in such a way that hybrids are unlikely and add synodontis multipunctatus for fry control.
If you want a conversation piece, choose a rare fish or an oddball fish. If you want whimsy, choose a goofy looking fish. If you want a testament to man's ability to create something unique, choose a man-made hybrid fish. If that is your goal, it could very well be worth it to you. :thumb: