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Bristlenose pleco no. Synodontis minimize the chance of survivors in the tank. You just remove the holding mom before she spits out the babies to another tank and you can still raise fry with a pleco and with Synodontis.
 

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I have had synos and plecos my whole life, and I have had some horny fish. Let's just say that no, it doesn't prevent births.
 
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