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I say the more water changes the better. I don't know what treatment you are using, but in general, by the time the directions say to add another dose, the first dose is no longer active. With ich- you can help remove the organisms by siphoning the substrate during treatment.

So, without knowing what drugs, what size tank, or what fish you are treating, I still think it's a good idea to do a 50% water change before the next dose.
 
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